October 30th, 2020

Grant to aid in developing new treatments for Alzheimer’s disease


By Jensen, Randy on October 1, 2020.

University of Lethbridge neuroscience professor Majid Mohajerani and two partners from Laval University are creating new tools for neuroscience research that they’ll use to test out a promising drug target for Alzheimer’s disease. University of Lethbridge photo

LETHBRIDGE HERALD

The University of Lethbridge’s Majid Mohajerani and two partners from Laval University are creating new tools for neuroscience research that they’ll use to test out a promising drug target for Alzheimer’s disease. If successful, their research could lead to new treatments to prevent the onset of Alzheimer’s disease symptoms, delay progression of the disease or even restore normal function after symptoms have appeared.

The research is made possible thanks to a grant of nearly $1 million over three years from the Weston Brain Institute, a non-profit institute of the W. Garfield Weston Foundation that supports world-class neuroscience research to accelerate discovery of treatments for neurodegenerative diseases such as Alzheimer’s and Parkinson’s.

“New treatments for these diseases are critically needed,” says Mohajerani, a professor of neuroscience at the U of L’s Canadian Centre for Behavioural Neuroscience (CCBN), in a news release. “Alzheimer’s disease has an enormous impact on patients, the health-care system and society. This is only anticipated to get worse as the population ages. Current treatments for Alzheimer’s disease only address some of the symptoms. They do not prevent or alter the course of the disease.”

In the project, Mohajerani, along with Laval University’s Benoit Gosselin and Yves De Koninck, will develop a device that allows for minimally invasive stimulation and recording of brain activity in mice in their home cages. The device includes a wireless transmitter, thus removing the need for the animal to be taken from its home cage and hooked up to wires in the lab. This implant will be combined with an automated monitoring system, currently under development at the CCBN, that records the animal’s natural behaviour. Together, these devices will allow scientists to measure the brain activity and behaviour of an animal in its home environment over days, weeks or even months.

The technology will enable them to address the idea that abnormal brain activity, characterized by an imbalance between excitatory and inhibitory connections in the brain, underlies the early progression of Alzheimer’s. De Koninck is a world expert on a certain protein, found on the outer membranes of cells within the nervous system, called potassium chloride co-transporter 2 (KCC2). An increase or decrease in the production of KCC2 affects the balance of inhibitory and excitatory activity in the brain. Pharmaceutical tools that target KCC2 might thus be able to correct the imbalance observed in Alzheimer’s, as well as other nervous system disorders such as chronic pain.

“We are using drugs that modulate the expression of KCC2,” says Mohajerani. “We will increase and also decrease the production of KCC2 to study both effects. We will explore if activation of KCC2, by boosting neuronal inhibition, can reduce the progression of the disease and if inhibition of KCC2 will increase the progression of the disease.”

Using genetically modified mice that model Alzheimer’s disease pathology and symptoms, the project aims to accelerate the development of therapeutics for Alzheimer’s by testing how altering KCC2 function affects brain activity and behaviour during disease progression in living animals. If successful, this research would implicate KCC2 as an entirely new drug target for mitigating Alzheimer’s disease.

Share this story:

8
Subscribe
Notify of
3 Comments
Oldest
Newest Most Voted
Inline Feedbacks
View all comments
susan12

My husband was diagnosed with PD and dementia. He started having hallucinations, lost touch with reality. Suspecting it was the medication I took him off the Siferol (with the doctor’s knowledge) and started him on PD natural herbal formula we ordered from AKANNI HERBAL CENTRE, his symptoms totally declined over a 3 weeks use of the AKANNI HERBAL Parkinsons disease natural herbal formula. He is now almost 51 and doing very well, the disease is totally reversed!  (Visit www. akanniherbalcentre .com)

susan12

My husband was diagnosed with PD and dementia. He started having hallucinations, lost touch with reality. Suspecting it was the medication I took him off the Siferol (with the doctor’s knowledge) and started him on PD natural herbal formula we ordered from AKANNI HERBAL CENTRE, his symptoms totally declined over a 3 weeks use of the AKANNI HERBAL Parkinsons disease natural herbal formula. He is now almost 51 and doing very well, the disease is totally reversed! (Visit www. akanniherbalcentre .com)

phlipl599@gmail.com

WorldHerbsClinic Parkinson’s disease herbal FORMULA helped my dear husband. I feel so bad for him because this is a hard disease and he tried and tried and gets so frustrated. Over 2 months plus now maybe or so he has been taking this product and he is doing good. I see it happening too. He is happier and buttons his own shirts now. My husband is a good guy and we have been married for 51 years. This disease takes a person away slowly and it painful. But now my dear husband is more like himself again. He is more spry and has his wits about him. I think he is more sassy though, but I count all as good, as before he just really stopped talking. Now we talk again and I missed him so much. Thanks to World Herbs Clinic for this product. We don’t have much time left in this world and you have given us more time together. Thanks again. I hope this review works ok and that I do it right. I am not good on the computer. This website will tell you more about World Herbs Clinic.(www worldherbsclinic com).



3
0
Would love your thoughts, please comment.x
()
x